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1.Cells in the liver. Functions in health and disease. Fabio Marra, Maurizio Parola 2.Physiology of liver function. Jean Fran ois Dufour, Alexander Sendensky 3.Assessment of liver function in clinical practice Hamed Khalili MD, Lawrence S. Friedman MD, Barham Abu Dayyeh, MD 4.Physiology of the splanchnic and hepatic circulations. Gautam Mehta, Juan-Carlos Garc a-Pag n, Jaime Bosch 5.Fibrosis as main mechanism of chronic liver disease. Lars P. Bechmann, Scott L. Friedman 6.Stem cells in the liver Aiwu Ruth He, Arun Thenappan, Feras J Abdul Khalek, Lopa Mishra 7.The role of inflammatory mediators in liver failure Joan Cl ria, Marta L pez-Parra, Esther Titos, Ana Gonz lez-P riz. 8.Genomics of the liver in health and disease Kostas Lazaridis, MD PART II. EFFECTS OF LIVER FAILURE ON ORGAN SYSTEMS 9.Hepatic encephalopathy and alterations of cerebral function Juan C rdoba, Rita Garc a Martinez 10.Bacterial translocation and alterations of the digestive system Reiner Wiest 11.SIRS, bacterial infections and alterations of the immune system Rajiv Jalan, 12.Extracellular fluid volume regulation and renal function. Jens Henriksen, . 13.The heart in chronic liver failure. Hongqun Liu, Soon Woo Nam, Samuel S. Lee 14.Hemostasis abnormalities in chronic liver failure. Armando Tripodi, . 15.The systemic and splanchnic circulations., Yasuko Iwakiri Ph.D. 16.Liver microcirculation. Chittaranjan Routray, Vijay Shah 17.Angiogenesis in liver diseases. Manuel Morales-Ruiz, S nia Tugues, Wladimiro Jim nez 18.Pulmonary alterations in chronic liver failure Michael J. Krowka MD, Aynur Okcay MD 19.Adrenal function in chronic liver failure Javier Fern ndez, . PART III. MANAGEMENT OF CHRONIC LIVER FAILURE 20.Antibiotic prophylaxis and management of bacterial infections. Joseph K. Lim, M.D., Puneeta Tandon, M.D., Guadalupe Garcia-Tsao, M.D. 21.Management of ascites and hyponatremia Andr's C rdenas, Pere Gin's 22.Management of renal failure. Vicente Arroyo, MD and M nica Guevara, MD 23.Therapy of Hemostasis abnormalities in chronic liver failure. Andrew Burroughs 24.Prevention and management of gastrointestinal bleeding. Juan G. Abraldes, Jaime Bosch, Juan Carlos Garc a-Pagan 25.Extracorporeal artificial liver support systems. Rafael Ba ares, Mar a-Vega Catalina 26.Issues in transplantation of patients with chronic liver failure. Michael D. Leise, W. Ray Kim, Patrick S. Kamath 27.Management of chronic liver failure in the intensive care unit. Dr Andrew Slack, Dr Julia Wendon.